C(21)-C(40) of tetrafibricin via metal catalysis: beyond stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles |
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| Authors: | Kumpulainen Esa T T Kang Byungsoo Krische Michael J |
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| Institution: | University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, United States. |
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| Abstract: | The C(21)-C(40) fragment of fibrinogen receptor inhibitor tetrafibricin was prepared in 12 steps from propane diol (longest linear sequence). In this approach, 6 C-C bonds are formed via asymmetric iridium catalyzed transfer hydrogenative carbonyl allylation and 2 C═C bonds are formed via Grubbs olefin cross-metathesis. |
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