Xanthone natural products via N-heterocyclic carbene catalysis: total synthesis of atroviridin |
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Authors: | Suzuki Yumiko Fukuta Yoshinori Ota Shinya Kamiya Masayo Sato Masayuki |
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Institution: | School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. suzuyumi@u-shizuoka-ken.ac.jp |
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Abstract: | The total synthesis of atroviridin has been accomplished by a linear route involving the N-heterocyclic carbene (NHC)-catalyzed aroylation of the fluorobenzene derivative, Claisen cyclization of the O-propargylated benzophenones, and intramolecular 1,4-addition of the quinone intermediates. The result provides a viable route to xanthone natural products. |
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