Angustimine and angustifolimine: two new alkaloids from Daphniphyllum angustifolium |
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| Authors: | Zhang Chuan-Rui Fan Cheng-Qi Dong Shi-Hui Liu Hong-Bing Zhou Wen-Bin Wu Yan Yue Jian-Min |
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| Affiliation: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China. |
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| Abstract: | Two new alkaloids, angustimine (1) featuring an unprecedented skeleton, and angustifolimine (2) being a rare diamino Daphniphyllum alkaloid, were isolated from Daphniphyllum angustifolium. Their structures were elucidated by extensive spectroscopic analysis. The biosynthetic origin of 1 was postulated. Cytotoxic activities of 1 and 2 were tested, and all of them were inactive. |
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