Efficient palladium-catalyzed cross-coupling of beta-chloroalkylidene/arylidene malonates using microwave chemistry |
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Authors: | Poondra Rajamohan R Fischer Peter M Turner Nicholas J |
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Affiliation: | School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, U.K. |
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Abstract: | A general method for the synthesis of beta-aryl/alkylarylidene malonates is reported. The key step involves the coupling of an arylboronic acid to a beta-chloroalkyl/arylidene malonate, in the presence of K2CO3 and 1 mol % of the air-stable palladium catalyst (POPd) under microwave irradiation, to afford beta-aryl/alkylarylidene malonates in good yields. The combination of mild reaction conditions, air stable catalyst, microwave-enhanced chemistry, and high levels of functional group compatibility make this an attractive synthetic approach to this class of compounds. |
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