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惊恐对鼠体组织损伤和中药保护机理的FTIR光谱法研究
引用本文:王米渠,孙素琴,张卫.惊恐对鼠体组织损伤和中药保护机理的FTIR光谱法研究[J].光谱学与光谱分析,2003,23(4):689-691.
作者姓名:王米渠  孙素琴  张卫
作者单位:1. 成都中医药大学,四川,成都,610075
2. 清华大学化学系,北京,100084
基金项目:国家自然科学基金 (批号 39570 848和 39870 957)资助项目
摘    要:首次利用微钻石衰减全反射傅里叶变换红外光谱法 (ATR/FTIR)研究了天敌惊恐对小鼠组织的损伤。结果表明 :惊恐后小鼠肾与足表面脂类化合物明显增高 ;服用补肾天然药物后 ,与正常对照组相比 ,脂类化合物变化不明显 ,进而说明药补可缓和压力 ,起到一定的调节作用。惊恐后小鼠心、肝和脑组织的红外谱没有变化 ,这是因为各个脏器对皮质激素的敏感程度不完全一样。

关 键 词:傅里叶变换红外光谱  鼠肾组织  鼠足表面组织  惊恐  中药
文章编号:1000-0593(2003)04-0689-03
修稿时间:2001年3月26日

Study on the Scathe of the Stressed Mouse Tissue and the Mechanism of Protection with Traditional Chinese Medicine by ATR/FTIR
WANG Mi-qu ,SUN Su-qin ,ZHANG Wei .Chengdu University of Traditional Chinese Medicine,Chengdu ,China.Study on the Scathe of the Stressed Mouse Tissue and the Mechanism of Protection with Traditional Chinese Medicine by ATR/FTIR[J].Spectroscopy and Spectral Analysis,2003,23(4):689-691.
Authors:WANG Mi-qu  SUN Su-qin  ZHANG Wei Chengdu University of Traditional Chinese Medicine  Chengdu  China
Institution:WANG Mi-qu 1,SUN Su-qin 2,ZHANG Wei 1 1.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China 2.Department of Chemistry,Tsinghua University,Beijing 100084,China
Abstract:The effects of stressed mouse tissue have been studied for the first time by ATR/FTIR.Comparing the threatened group with the control group,the intensity of absorbance of fat was significantly increased.Comparing the threatened group having taken kidney tonic of Chinese medicine with the control group,the change in peaks of fat was not obvious.The results showed that the medicine could alleviate stress and exert the function of regulation.The FTIR spectra of heart,liver and brain tissues did not change after the mouse was frightened,which suggested that the sensitive degree of different organs to adrenocortical steroid was not equal.
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