Electrochemical characteristics of gatifloxacin and its interaction with DNA. |
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| Authors: | Ming Guo Qing-Sen Yu |
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| Affiliation: | Department of Chemistry, Zhejiang Forestry University, LinAn, China. tdky@hotmail.com |
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| Abstract: | The electrochemical behavior of gatifloxacin (GTFX) and its interaction with natural calf thymus DNA (ctDNA) is investigated by differential pulse voltammetry (DPV) on a carbon paraffined electrode. According to the suggested electrochemical equation, a binding constant of 1.7058 x 10(5) (mol L(-1))(-1) and binding sizes s = 3.09 (base pairs) of GTFX with ctDNA are obtained by nonlinear fit analysis of electrochemical data. The results demonstrate that GTFX has the properties of an intercalative binder. |
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