Diclofenac sodium-loaded solid lipid nanoparticles prepared by emulsion/solvent evaporation method |
| |
Authors: | Dongfei Liu Sunmin Jiang Hong Shen Shan Qin Juanjuan Liu Qing Zhang Rui Li Qunwei Xu |
| |
Institution: | (1) School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing, People’s Republic of China;(2) Neuro-Psychiatric Institute, Nanjing Brain Hospital Affiliated to Nanjing Medical University, 264 Guangzhou Road, Nanjing, People’s Republic of China; |
| |
Abstract: | The preparation of solid lipid nanoparticles (SLNs) suffers from the drawback of poor incorporation of water-soluble drugs.
The aim of this study was therefore to assess various formulation and process parameters to enhance the incorporation of a
water-soluble drug (diclofenac sodium, DS) into SLNs prepared by the emulsion/solvent evaporation method. Results showed that
the entrapment efficiency (EE) of DS was increased to approximately 100% by lowering the pH of dispersed phase. The EE of
DS-loaded SLNs (DS-SLNs) had been improved by the existence of cosurfactants and increment of PVA concentration. Stabilizers
and their combination with PEG 400 in the dispersed phase also resulted in higher EE and drug loading (DL). EE increased and
DL decreased as the phospholipid/DS ratio became greater, while the amount of DS had an opposite effect. Ethanol turned out
to be the ideal solvent making DS-SLNs. EE and DL of DS-SLNs were not affected by either the stirring speed or the viscosity
of aqueous and dispersed phase. According to the investigations, drug solubility in dispersion medium played the most important
role in improving EE. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|