Voltammetric investigation and amperometric detection of the bisphosphonate drug sodium alendronate using a copper nanoparticles-modified electrode |
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| Authors: | Heli Hossein Faramarzi F Sattarahmady N |
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| Institution: | (1) Laboratory of Analytical and Physical Electrochemistry, Department of Chemistry, Islamic Azad University, Fars Science and Research Branch, P.O. Box 73715-181, Marvdasht, Iran;(2) Young Researchers Club, Islamic Azad University, Fars Science and Research Branch, Marvdasht, Iran;(3) Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran;(4) Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | The electrochemical behavior of sodium alendronate on copper microparticle- and copper nanoparticle-modified carbon paste
electrodes was investigated. In the voltammograms recorded using microparticles, a single anodic oxidation peak appeared,
while using nanoparticles, two anodic peaks appeared. The anodic currents were related to the electrocatalytic oxidation of
alendronate via the active species of Cu(III). The catalytic rate constant for the electrocatalytic oxidation process and
the diffusion coefficient of alendronate were obtained to be 1.57 × 103 cm3 mol−1 s−1 and 2.44 × 10−6 cm2 s−1, respectively. A sensitive and time-saving detection procedure was developed for the analysis of alendronate, and the corresponding
analytical parameters were reported. Alendronate was determined with a limit of detection of 11.26 μmol L−1 with a linear range of 50–6,330 μmol L−1. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets, and the results were
in good agreement with the declared values. |
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