Macrocyclic antibiotics as chiral selectors in the design of enantioselective, potentiometric membrane electrodes for the determination of S-flurbiprofen |
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Authors: | Raluca-Ioana Stefan-van Staden Jacobus F. van Staden Hassan Y. Aboul-Enein |
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Affiliation: | (1) Laboratory of Electrochemistry Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str, 060021 Bucharest, Romania;(2) Pharmaceutical and Drug Industries Research Division, National Research Center (NRC), Dokki, Cairo, 12662, Egypt |
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Abstract: | Construction of three novel enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with different macrocyclic antibiotics vancomycin and teicoplanin as chiral selectors are described. The solutions for the construction of electrodes were prepared in phosphate buffer pH 4 for the vancomycin-based electrode (VCM), pH 6 and pH 6/40% acetonitrile solutions for teicoplanin-based electrodes, TCP I and II, respectively. The proposed electrodes were applied in the assay of S-flurbiprofen raw material and its pharmaceutical formulation by use of direct potentiometry, VCM electrode exhibiting the best enantioselectivity. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper. |
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Keywords: | Enantioselective Potentiometric membrane electrode Enantioselective assay Vancomycin Teicoplanin S-flurbiprofen |
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