Biocatalytic and biomimetic aminolysis reactions: useful tools for selective transformations on polyfunctional substrates |
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Authors: | Alfonso Ignacio Gotor Vicente |
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Affiliation: | Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/ Julián Clavería, 8, E-33071 Oviedo, Spain. |
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Abstract: | Aminolysis is a deeply studied reaction, but the development of new catalysts for this process is still an emerging area of organic and bioorganic chemistry. Two different approaches are reviewed in this article: the biomimetic de novo designed synthetic catalysts and the use of natural enzymes. Brief mechanistic considerations are discussed. Some important aspects like chemo-, regio- and stereoselectivity towards the substrates are highlighted on selected examples with synthetic applications. |
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