| 3-苯基异香豆冉酮衍生物的不对称Mannich反应研究 |
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| 引用本文： | 刘灏,蒋琳. 3-苯基异香豆冉酮衍生物的不对称Mannich反应研究[J]. 合成化学, 2010, 18(2) |
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| 作者姓名： | 刘灏 蒋琳 |
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| 作者单位： | 四川大学,华西药学院,四川,成都,610041;四川大学,华西药学院,四川,成都,610041 |
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| 摘 要： | 研究了双功能手性硫脲-叔胺催化剂催化的3-苯基异香豆冉酮衍生物与N-保护亚胺的不对称Mannich反应,高收率、高对映选择性(88%~98%)地合成了一系列具有连续季碳叔碳手性中心的新化合物,其结构经1HNMR和13C NMR表征。
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| 关 键 词： | 不对称催化 3-苯基异香豆冉酮 衍生物 Mannich反应 硫脲-叔胺催化剂 |
Study on the Mannich Reaction of 3-Phenyl Isocoumaranone Derivatives |
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| LIU Hao,JIANG Lin. Study on the Mannich Reaction of 3-Phenyl Isocoumaranone Derivatives[J]. Chinese Journal of Synthetic Chemistry, 2010, 18(2) |
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| Authors: | LIU Hao JIANG Lin |
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| Abstract: | The asymmetric Mannich reaction of 3-phenyl isocoumaranone derivatives and N-protected imines were investigated using bifunctional thiourea-tertiary amine as the catalyst. A series of novel transformation afforded Mannich adducts bearing adjacent quaternary carbon and tertiary carbon chiral centers with high yield and excellent enantioselectivities(88%ee～98%ee). The structures were characterized by ~1H NMR and ~(13)C NMR. |
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| Keywords: | asymmetric catalysis 3-phenyl isocoumaranone derivative Mannich reaction thiourea-tertiary amine catalyst |
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