| Synthesis of Nonionic Oligomeric Manganese(Ⅱ) Complexes and Investigation of Their Toxicity andΤ_1-Relaxation Enhancement |
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| 作者单位： | YU Kai-chao~1，2，LI Ying-xia~1，ZHOU Jin-lan~2**，DING Shang-wu~1，3 and YE Chao-hui~1 1. State Key Laboratory of Magnetic Resonance & Atomic and Molecular Physics，Wuhan Institute of Physics and Mathematics，the Chinese Academy of Sciences，Wuhan 430071，P. R. China;2. Department of Chemistry，Huazhong University of Science and Technology，Wuhan 430074，P. R. China;3. Department of Chemistry and Center for Nano Science & Nano Technology，National Sun Yat-Sen University，Kaohsiung，80424 Taiwan，ChinaReceived Nov.23，2004 |
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| 基金项目： | Supported by the National Natural Science Foundation of China(Nos. 20275011 and 10234070)，the Program for PromotingUniversity Academic Excellence by the Ministry of Education of Taiwan of China(No. A-92-N-FA01-2-4-5)，Foundation of StateKey Laboratory of Magnetic Resonance &Atomic and Molecular Physics(No. T12045). |
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| 摘 要： | Introduction Non-invasive and accurate imaging of human inter-nal organs is crucial for medical diagnosis. Lauterburand Mansfield were awarded the 2003 Nobel Prize inphysiology and medicine, respectively, for their semi-nal work concerning magnetic resonance imaging(MRI)1]. This powerful technique represents a break-through in medical diagnostics as well as in other myri-ad fields such as chemistry, physics, materials scienceand biology. Throughout the development of the MRItechnique, a g…
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| 关 键 词： | Magnetic resonance imaging(MRI) Oligomeric contrast agent Nonionic Mn(Ⅱ) complex Relaxivity Acute toxicity Relaxation enhancement |
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