Esters of Substituted 2,3,7-Triazabicyclo[3.3.0]oct-3-ene-4-carboxylic acids and 1,2,7-Triazaspiro[4.4]non-2-ene-3-carboxylic acids in Alkylation and Acylation

Esters of substituted 2,3,7-triazabicyclo3.3.0]oct-3-ene-4-carboxylic acids react with acetone in the presence of hydrogen chloride (bromide) affording esters of substituted 2-(1,1-dimethyl-3-oxobutyl)-2,3,7-triazabicyclo3.3.0]oct-3-ene-4-carboxylic acids. Reactions of esters of substituted 2,3,7-triazabicyclo3.3.0]octa-1(5),3-diene-4-carboxylic acids with 1-adamantanol in trifluoroacetic acid resulted in esters of substituted 2-(1-adamantyl)- 2,3,7-triazabicyclo3.3.0]octa-1(5),3-diene-4-carboxylic acids.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 2, 2005, pp. 252–263.Original Russian Text Copyright © 2005 by Stepakov, Molchanov, Kostikov.