| 爱博霉素B的全合成研究进展 |
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| 引用本文： | 吕宜春,;崔庆华. 爱博霉素B的全合成研究进展[J]. 化学研究, 2014, 0(5): 527-533 |
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| 作者姓名： | 吕宜春, 崔庆华 |
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| 作者单位： | [1]山东化工职业学院化学工程系,山东淄博255400; [2]滨州市环境保护科学技术研究所,山东滨州256606 |
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| 摘 要： | 爱博霉素B是16元环的大环内酯类化合物,以其独特的抗癌性能和复杂新颖的化学结构而受到越来越多的化学工作者的关注,从发现至今已有许多研究小组报道了相关的全合成研究成果.本文作者综述了其合成研究进展,分析了各合成路线的关键步骤,讨论了某些路线的优缺点,并对该药的研究前景进行了展望.
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| 关 键 词： | 爱博霉素B 抗癌 全合成 研究进展 |
Progress in total synthesis of Epothilone B |
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| LV Yichun;CUI Qinghua. Progress in total synthesis of Epothilone B[J]. Chemical Research, 2014, 0(5): 527-533 |
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| Authors: | LV Yichun CUI Qinghua |
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| Affiliation: | LV Yichun, CUI Qinghua (1.Department of Chemical Engineering, Shandong Vocational College of Chemical Engineering, Zibo 255400 Shandong, China ; 2. Institute of Environment Protection Science and Technology of Binzhou City Binzhou 256606, Shandong, China) |
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| Abstract: | Epothilone B is a macrolide,and it has attracted more and more attention from chem-ical researchers,due to its unique novel anti-cancer properties and complex chemical structure. Several research teams have reported the total synthesis of Epothilone B.This review focuses on the research progress in the synthesis of Epothilone B.The key steps of various synthetic routes are analyzed,and the advantages and disadvantages of some synthetic routes are briefed. Moreover,suggestions are given about the development trend of Epothilone B. |
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| Keywords: | Epothilone B anti-cancer total synthesis research progress |
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