Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers |
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Authors: | Kim Ki-Hyun Lee Jong-Chan Lee Jonghwi |
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Institution: | School of Chemical and Biological Engineering, Seoul National University, Shillim-9-Dong, Gwanak-Gu, Seoul 151-744, Republic of Korea. |
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Abstract: | Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximately 10(-8) M) than for conventional surfactants and block copolymers. |
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Keywords: | drug‐delivery systems micelles non‐linear polymers particle size distribution water‐soluble polymers |
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