Thionation of amides using a solid-supported P2S5 reagent under microwave irradiation |
| |
| Authors: | Helen Rachel LagiakosAshley Walker Marie-Isabel AguilarPatrick Perlmutter |
| |
| Institution: | a School of Chemistry, Monash University, Clayton VIC 3800, Australia
b Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia |
| |
| Abstract: | In this Letter, we describe an improved method for the thionation of amides. Using a solid-supported P2S5 reagent, heating under microwave irradiation furnished thioamides in good to excellent yields, with a significantly reduced reaction time compared with that achieved under conventional heating. Furthermore, a change of solvent from that described in the literature enabled a simplified work-up and purification of the products. |
| |
| Keywords: | Thionation Microwave irradiation Phosphorus pentasulfide Solid-supported reagent |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
