A reductive-Heck approach to the hydroazulene ring system: a formal synthesis of the englerins |
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| Authors: | Gao Peng Cook Silas P |
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| Institution: | Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA. |
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| Abstract: | The reduction of a palladium enolate prior to β-hydride elimination provides a unique reaction for the synthesis of the hydroazulene ring system. When combined with a transannular epoxide rearrangement cascade, the reductive-Heck reaction allows rapid entry to the oxo-bridged guaiane core of the englerins. |
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