Assembly of a supramolecular capsule on a molecular printboard |
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Authors: | Corbellini Francesca Mulder Alart Sartori Andrea Ludden Manon J W Casnati Alessandro Ungaro Rocco Huskens Jurriaan Crego-Calama Mercedes Reinhoudt David N |
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Institution: | Laboratory of Supramolecular Chemistry and Technology, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. |
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Abstract: | A molecular capsule based on ionic interactions between two oppositely charged calix4]arenes, 1 and 2, was assembled both in solution and on a surface. In solution, the formation of the equimolar assembly 1.2 was studied by (1)H NMR, ESI-MS, and isothermal titration calorimetry, giving an association constant (K(a)) of 7.5 x 10(5) M(-1). A beta-cyclodextrin self-assembled monolayer (beta-CD SAM) on gold was used as a molecular printboard to anchor the tetraguanidinium calix4]arene (2). The binding of tetrasulfonate calix4]arene 1 was monitored by surface plasmon resonance spectroscopy. Rinsing of the surface with a high ionic strength aqueous solution allows the removal of the tetrasulfonate calix4]arene (1), while by rinsing with 2-propanol it is possible to achieve the complete desorption of the tetraguanidinium calix4]arene (2) from the beta-CD SAM. The K(a) for the capsule formation on a surface is 3.5 x 10(6) M(-1), thus comparing well with the K(a) determined in solution. |
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