Direct separation of the enantiomers of cetirizine and related compounds by reversed-phase chiral HPLC |
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| Authors: | Q Liu Z Zhang H Bo R A Sheldon |
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| Institution: | (1) Institute of Chemistry and Chemical Engineering, Hebei Normal University, 050091 Hebei, Shijiazhuang, P.R. China;(2) Laboratory of Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628BL Delft, The Netherlands |
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| Abstract: | Summary Direct separations of the enantiomers of cetirizine and related compounds have been achieved by reversed-phase HPLC on the
Chiralcel OD-R, a polysaccharide-derived chiral stationary phase; the mobile phase was usually perchlorate solution supplemented
with acetonitrile. Resolution of the enantiomers of cetirizine and related compounds was good. The effect of the acetonitrile
content of the mobile phase was investigated, and the effect of the structure of the chiral compounds on their behavior on
the Chiralcel OD-R column is discussed. |
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| Keywords: | Column liquid chromatography Chiral stationary phase Enantiomer separation Chiral drugs Cetirizine |
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