A flexible enantioselective synthesis of the isofurans |
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| Authors: | Taber Douglass F Pan Yongchun Zhao Xia |
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| Institution: | Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberdf@udel.edu |
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| Abstract: | Recently, the isolation of a new class of human arachidonic acid tetrahydrofuran oxidation products, the isofurans (IsoF's), was reported. These new compounds are available from natural sources only in microgram quantities as mixtures. The enantioselective preparation of a versatile epoxide intermediate and its conversion to the enantiomerically pure isofurans SC-Delta(13)-9-IsoF and 15-epi-SC-Delta(13)-9-IsoF are described. This synthesis will make these metabolites available for physiological evaluation. |
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