基质金属蛋白酶抑制剂设计的研究进展*

基质金属蛋白酶(MMP) 是一类含锌的水解酶, 过量的MMP会加速细胞外基质的降解并导致一系列的疾病, 例如癌症、关节炎和多发性硬化症等。因此MMP抑制剂的研究已成为药物设计研究领域中的一个热门课题。近年来, 科学家们发展了三种分子设计的方法, 包括基于底物的药物设计、基于结构的药物设计和组合化学技术。本文介绍了这些方法的原理及其在MMP抑制剂设计中的应用和进展。

Progress in the Design of Matrix Metalloproteinase Inhibitors

Matrix metalloproteinase (MMP) is a family of zinc proteinases. The excess of these proteinases leads to the accelerated extracellular matrix degradation associated with diseases such as arthritis, cancer and multiple sclerosis. The research of MMP inhibitors is an active field of drug design. In recent years, three methods of molecular design have been developed, including substrate based design,structure based design and combinatorial chemistry technology. The principle of these methods and their applications in MMP inhibitor design are summarized in this review.