Dopamine sensor based on molecularly imprinted electrosynthesized polymers |
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Authors: | Song Wei Chen Yu Xu Juan Yang Xiao-Rong Tian Dan-Bi |
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Institution: | (1) College of Science, Nanjing University of Technology, Nanjing, 210009, People’s Republic of China; |
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Abstract: | Molecularly imprinted polymers (MIPs) have been applied as molecular recognition elements to chemical sensors. In this paper,
we combined the use of MIPs and electropolymerization to produce a sensor which was capable of detecting dopamine (DA). The
MIP electrode was obtained by electrocopolymerization of o-phenylenediamine and resorcinol in the presence of the template molecular DA. The MIP electrode exhibited a much higher current
response compared with the non-imprinted electrode. The response of the imprinted sensor to DA was linearly proportional to
its concentration over the range 5.0 × 10−7-4.0 × 10−5 M. The detection limit of DA is 0.13 μM (S/N = 3). Moreover, the proposed method could discriminate between DA and its analogs, such as ascorbic acid and uric acid. This
method was successfully applied to the determination of DA in dopamine hydrochloride injection and healthy human blood serum.
These results revealed that such a sensor fulfilled the selectivity, sensitivity, sped, and simplicity requirements for DA
detection and provided possibilities of clinical application in physiological fields. |
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