Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays |
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Authors: | Maksym V Kopanitsa Nurudeen O Afinowi Seth GN Grant |
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Institution: | (1) Genes to Cognition Programme, The Wellcome Trust Sanger Institute,Genome Campus, CB101SA Cambridge, Hinxton, UK |
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Abstract: | Background Multi-electrode arrays (MEAs) have become popular tools for recording spontaneous and evoked electrical activity of excitable
tissues. The majority of previous studies of synaptic transmission in brain slices employed MEAs with planar electrodes that
had limited ability to detect signals coming from deeper, healthier layers of the slice. To overcome this limitation, we used
three-dimensional (3D) MEAs with tip-shaped electrodes to probe plasticity of field excitatory synaptic potentials (fEPSPs)
in the CA1 area of hippocampal slices of 129S5/SvEvBrd and C57BL/6J-TyrC-Brd mice. |
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Keywords: | |
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