Asymmetric total synthesis of clavolonine |
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Authors: | Nakahara Kenji Hirano Kie Maehata Ryota Kita Yasuyuki Fujioka Hiromichi |
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Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871 Japan. |
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Abstract: | The asymmetric total synthesis of clavolonine (1) has been achieved based on chiral auxiliary multiple-use methodology. Our synthetic route features stereoselective transformations on the cyclohexane ring utilizing the steric environment of the chiral auxiliary and an intramolecular Mannich reaction to construct the fused ring system. |
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