Synthesis,Properties, and Reactions of 5-Substituted Derivatives of 2,3-Diphenylquinoxaline [1] |
| |
| Authors: | Jozef?Saloň Email author" target="_blank">Viktor?MilataEmail author Miloslav?Chudík Nade?da?Prónayová Ján?Le?ko Milan?Seman Anna?Belicová |
| |
| Institution: | (1) Department of Organic Chemistry, Faculty of Chemical Technology, Slovak Technical University, SK-812 37-Bratislava, Slovakia;(2) Central laboratory of Chemical Technique, Faculty of Chemical Technology, Slovak Technical University, SK-812 37-Bratislava, Slovakia;(3) Institute of Cells Biology, Faculty of Natural Sciences of the Comenius University, SK-811 07 Bratislava, Slovakia |
| |
| Abstract: | Summary. Catalytic hydrogenation of 5-nitro-2,3-diphenylquinoxaline led to the corresponding amine which, in turn, afforded products of nucleophilic substitution on reaction with alkoxymethylene derivatives. Thermal cyclization of selected alkoxymethylene derivatives yielded substituted pyridoquinoxalines. The conditions for successful hydrolysis of ester, decarboxylation of the acid, following chlorination of pyridone and reductive removal of the chlorine atom from it to produce parental heterocycle 2,3-diphenyl-pyrido2,3-f]quinoxaline were found. All of the tested products of the nucleophilic substitution showed no antibacterial activity.Dedicated to Prof. Dr. M. Uher on the occasion of his 65th birthday |
| |
| Keywords: | , Nucleophilic substitutions, Enols, Cyclizations, Pyridoquinoxalines, Antibacterial activity, |
| 本文献已被 SpringerLink 等数据库收录！ |
|
