Structure and absolute stereochemistry of the anticancer agent EBC-23 from the Australian rainforest |
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| Authors: | Dong Lin Gordon Victoria A Grange Rebecca L Johns Jenny Parsons Peter G Porzelle Achim Reddell Paul Schill Heiko Williams Craig M |
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| Affiliation: | School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia. |
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| Abstract: | EBC-23 (2), a prostate anticancer agent, was isolated from the fruit of Cinnamomum laubatii (family Lauraceae) in the Australian tropical rainforest. Extensive NOE experiments enabled the relative stereochemistry of the proposed EBC-23 (2) structure to be determined. Total synthesis of both enantiopodes over nine linear steps, involving challenging RCM and spiroacetal cyclizations, confirmed the gross structure and relative and absolute stereochemistry. |
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