| Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound |
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| 引用本文： | Zhi Jie XUE Yuan Chao LI. Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound[J]. 中国化学快报, 2005, 16(12): 1569-1572 |
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| 作者姓名： | Zhi Jie XUE Yuan Chao LI |
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| 作者单位： | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 |
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| 摘 要： | Polyhydroxy enyne compound （＋）-（1＇S, 2R, 3S, 5S, 6S）-5,6-dimethoxy-5, 6-dimethyl- 2-（1＇-hydroxylpropyl-2-ne）-3-vinyl-l,4-dioxane has been synthesized from D-（-）-tartaric acid. A new chiral center was established by nucleophilic addition with 87% de. The modified Mosher＇s method was employed to confirm the absolute configuration of 17, which assigned the S-configuration at the new chiral center.
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| 关 键 词： | 多羟烯炔化合物 酒石酸 亲核 手性拆分 合成方法 |
| 收稿时间： | 2005-03-21 |
Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound |
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| Zhi Jie XUE,Yuan Chao LI. Synthesis and Determination of Absolute Configuration of a Divergent Polyhydroxy Enyne Compound[J]. Chinese Chemical Letters, 2005, 16(12): 1569-1572 |
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| Authors: | Zhi Jie XUE Yuan Chao LI |
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