Microwave assisted Leimgruber-Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines |
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Authors: | Siu Jason Baxendale Ian R Ley Steven V |
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Institution: | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. |
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Abstract: | The development of enhanced conditions for Lewis acid catalysed Leimgruber-Batcho indole synthesis using microwave acceleration is described. This approach has permitted the preparation of a variety of heteroaromatic enamine intermediates in good yield and high purities. Subsequent catalytic hydrogenation reactions, under various conditions including the use of a solid-phase encapsulated catalyst, furnish the corresponding indole derivatives in good yields. |
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