Facilitated phosphatidylserine flip-flop across vesicle and cell membranes using urea-derived synthetic translocases |
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Authors: | Sasaki Yoshihiro Shukla Rameshwer Smith Bradley D |
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Institution: | Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556-5670, USA. |
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Abstract: | Tris(2-aminoethyl)amine derivatives with appended urea and sulfonamide groups are shown to facilitate the translocation of fluorescent phospholipid probes and endogenous phosphatidylserine across vesicle and erythrocyte cell membranes. The synthetic translocases appear to operate by binding to the phospholipid head groups and forming lipophilic supramolecular complexes which diffuse through the non-polar interior of the bilayer membrane. |
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