Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1) |
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| Authors: | Cryle Max J De Voss James J |
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| Affiliation: | Department of Chemistry, University of Queensland, St. Lucia, Brisbane, Australia 4072. |
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| Abstract: | Cytochrome p450(BioI)(CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional p450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported. |
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