Remarkable Anticancer Activity of Triruthenium-Arene Clusters Compared to Tetraruthenium-Arene Clusters |
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| Authors: | Bruno Therrien Wee Han Ang Frédéric Chérioux Ludovic Vieille-Petit Lucienne Juillerat-Jeanneret Georg Süss-Fink Paul J. Dyson |
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| Affiliation: | 1.Institut de Chimie,Université de Neuchatel,Neuchatel,Switzerland;2.Institut des Sciences et Ingénierie Chimiques,Ecole Polytechnique Fédérale de Lausanne (EPFL),Lausanne,Switzerland;3.Laboratoire FEMTO-ST, UMR CNRS 6174,Besan?on cedex,France;4.Centre Hospitalier Universitaire Vaudois (CHUV),University Institute of Pathology,Lausanne,Switzerland |
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| Abstract: | Abstract The in vitro activity of a series of ruthenium clusters, [(η6-C6H6)(η6-C6Me6)2Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)(η6-1,4-iPrC6H4Me)(η6-C6Me6)Ru3(μ-H)3(μ3-O)][BF4], [(η6-C6H6)4Ru4(μ-H)4][BF4]2, [(η6-C6H5Me)4Ru4(μ-H)4][BF4]2 and [(η6-C6H6)4Ru4(μ-H)3(μ-OH)][Cl]2, has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(η6-C6H5Me)4Ru4(μ-H)4][PF6]2 is also reported. Graphical Abstract The in vitro activity of a series of ruthenium clusters has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines and their activity compared to cisplatin. The triruthenium clusters are very active, while the tetraruthenium clusters do not display significant cytotoxicities.  Dedicated to Professor Dieter Fenske on the occasion of his 65th birthday anniversary |
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| Keywords: | Clusters bioorganometallic chemistry medicinal chemistry bioinorganic chemistry ruthenium in vitro assays anticancer drugs |
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