Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats |
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| Authors: | Jing Dong Wanyang Liu Yi Wang Yi Hou Qi Xi Jie Chen |
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| Affiliation: | (1) Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China;(2) Department of Physiology, Radboud University Nijmegen Medical Centre. Nijmegen, The Netherlands |
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| Abstract: | Background Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal extracellular signal-regulated kinase (ERK1/2) and cAMP response element-binding protein (CREB) are implicated in the impaired learning and memory in lactational and adolescent rat hippocampus following developmental ID and hypothyroidism. |
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