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In vitro nitrosation of ephedrine in the presence of cyclodextrins
Authors:V Wedelich  W Mehnert  K -H Frömming
Institution:(1) Institut für Pharmazie der Freien Universität Berlin, Königin-Luise-Str. 2+4, D-1000 Berlin 33, FRG
Abstract:beta-, and gamma-cyclodextrin and heptakis-2,6-di-O-methyl-beta-cyclodextrin enhance the nitrosation rate of l-ephedrine if the nitrosation assay procedure (NAP test) is applied. During this reaction with beta-cyclodextrin a solid inclusion compound of beta-cyclodextrin andN-nitrosoephedrine precipitates. Solubilities and stabilities of inclusion compounds of the cyclodextrins with ephedrine and nitrosoephedrine, respectively, explain especially the catalytic effects of some cyclodextrins on ephedrine.Part of the PhD thesis of V. Wedelich, Freie Universität Berlin, 1985.
Keywords:Nitrosation reactions  agr-" target="_blank">gif" alt="agr" align="BASELINE" BORDER="0">-  beta-" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-  gamma-cyclodextrin" target="_blank">gif" alt="gamma" align="MIDDLE" BORDER="0">-cyclodextrin  dimethyl-beta-cyclodextrin" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-cyclodextrin  ephedrine  nitrosoephedrine
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