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Development of Thiolated Chitosan Nanoparticles Based Mucoadhesive Vaginal Drug Delivery Systems |
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| Authors: | M. Hasanifard B. Ebrahimi-Hosseinzadeh A. Hatamian-Zarmi A. H. Rezayan M. A. Esmaeili |
| Affiliation: | 1.Department of Life Science Engineering, Faculty of New Sciences and Technologies,University of Tehran,Tehran,Iran;2.Medicinal Plants and Drug Research, Institute,Shahid Beheshti University, G.C.,Tehran,Iran |
| Abstract: | The aim of the present study was to evaluate the influence of the chitosan chain length on the drug loading and releasing in VFS (vaginal fluid simulant). Thiolated chitosan nanoparticles (TCS-NPs) were prepared using thioglycolic acid and 1-ethyl-3-3-(3-dimethylaminopropyl)carbodimide hydrochloride (EDC) and characterized with FTIR. The degree of thiol substitution was found out by Ellman’s method. TCS-NPs were developed using ionic cross-linking reaction with pentasodiumtripolyphosphate (TPP). Curcumin (CUR) loaded nanoparticles were obtained by encapsulation. DLS and SEM characterized these NPs with diameter between 200 ± 50 nm. Zeta potential of NPs was 11–38 mv. The maximal encapsulation efficiency was 86.26%. The in vitro drug release studies in VFA at pH 4.2 showed a sustained release profile over a period of 3 days. |
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