Synthetic studies with 13-deoxybaccatin III |
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| Authors: | Ahn Yu Mi Vander Velde David G Georg Gunda I |
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| Institution: | Department of Medicinal Chemistry and the Drug Discovery Program, Higuchi Biosciences Center, The University of Kansas, Lawrence, Kansas 66045-7582, USA. |
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| Abstract: | An efficient synthesis of 13-epi-7-O-(triethylsilyl)baccatin III from 13-deoxybaccatin III is described. Oxidation of 13-deoxy-7-O-(triethylsilyl)baccatin III with tert-butyl peroxide, followed by reduction with SmI(2), produced 13-epi-7-O-(triethylsilyl)baccatin III in good overall yield. The preparation of 13-oxo-7-O-(triethylsilyl)baccatin III from 13-epi-7-O-(triethylsilyl)baccatin III using tetrapropylammonium perruthenate and N-methylmorpholine N-oxide is also reported. |
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