| 水介质中1,6-二氧-5-氧代-1,4,5,6-四氢化菲衍生物的三组分一锅合成 |
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| 引用本文： | 史达清,王静,庄启亚,王香善. 水介质中1,6-二氧-5-氧代-1,4,5,6-四氢化菲衍生物的三组分一锅合成[J]. 有机化学, 2006, 26(5): 643-647 |
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| 作者姓名： | 史达清 王静 庄启亚 王香善 |
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| 作者单位： | 1. 徐州师范大学化学系,徐州,221116;江苏省药用植物生物技术重点实验室,徐州,221116
2. 徐州师范大学化学系,徐州,221116;徐州医学院,徐州,221002 |
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| 基金项目： | 江苏省药用植物生物技术重点实验室基金(No.03AXL13)资助项目. |
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| 摘 要： | 水介质中在氯化三乙基苄基铵(TEBA)催化下, 芳醛与丙二腈和4-羟基香豆素三组分一锅反应合成了2-氨基-4-芳基-3-氰基-1,6-二氧-5-氧代-1,4,5,6-四氢化菲, 该反应具有产率高、污染少、操作简单、环境友好等优点.
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| 关 键 词： | 1,6-二氧-5-氧代-1,4,5,6-四氢化菲 一锅合成 三组分 水介质 |
| 收稿时间： | 2005-03-01 |
| 修稿时间： | 2005-11-02 |
Three-Component One-Pot Synthesis of 1,6-Dioxa-5-oxo-1,4,5,6- tetrahydrophenanthrene Derivatives in Aqueous Media |
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| SHI Da-Qing,WANG Jing,ZHUANG Qi-Ya,WANG Xiang-Shan. Three-Component One-Pot Synthesis of 1,6-Dioxa-5-oxo-1,4,5,6- tetrahydrophenanthrene Derivatives in Aqueous Media[J]. Chinese Journal of Organic Chemistry, 2006, 26(5): 643-647 |
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| Authors: | SHI Da-Qing WANG Jing ZHUANG Qi-Ya WANG Xiang-Shan |
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| Affiliation: | a Department of Chemistry, Xuzhou Normal University, Xuzhou 221116; b Key Laboratory of Biotechnology on Medical Plants of Jiangsu Province, Xuzhou 221116;c Xuzhou Medical College, Xuzhou 221002 |
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| Abstract: | 2-Amino-4-aryl-3-cyano-1,6-dioxa-5-oxo-1,4,5,6-tetrahydrophenanthrenes were synthesized by a three-component reaction of aromatic aldehydes, malononitrile and 4-hydroxycoumarin using triethylben- zylammonium chloride as catalyst in aqueous media. The reaction has the advantages of good yields, less pollution, simple operation and environmental friendliness. |
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| Keywords: | 1 6-dioxa-5-oxo-1 4 5 6-tetrahydrophenanthrene one-pot synthesis three-component aqueous media |
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