Effect of membrane morphology on the initial rate of protein fouling during microfiltration |
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| Institution: | 1. Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan;2. Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan;3. Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan;1. Department of Electrochemistry, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama 226 8503, Japan;2. Division of Materials and Manufacturing Science, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565 0871, Japan;3. Department of Mechanical Science and Technology, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152 8550, Japan;4. Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 985 8577, Japan;5. Photocatalysis International Research Center, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan;6. Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152 8550, Japan;7. Department of Chemistry and Materials Science, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152 8550, Japan;1. Department of Neurology, Linkou Medical Center, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan;2. Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan;3. Institue of Microsystems and Nanoengineering, National Tsing Hua University, Hsinchu 30013, Taiwan;4. Department of Neurosurgery, Linkou Medical Center, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan 33305, Taiwan;5. Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu 30013, Taiwan;1. Technische Universität Darmstadt, Department of Materials and Earth Sciences, Alarich-Weiss-Straße 2, 64287 Darmstadt, Germany;2. Northeast Forestry University, College of Material Science and Engineering, 150040 Harbin, PR China;3. Dokuz Eylul University, Science Faculty, Department of Chemistry, Tinaztepe Kampusu, Buca, 35160 Izmir, Turkey;1. King Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences & Engineering Division (BESE), Thuwal 23955-6900, Saudi Arabia;2. King Abdullah University of Science and Technology (KAUST), Center for Numerical Porous Media (NumPor), Thuwal 23955-6900, Saudi Arabia;3. Weierstrass Institute for Applied Analysis and Stochastics, Berlin 10117, Germany;4. Curtin University, Applied Geology Department, Western Australian School of Mines, Faculty of Science and Engineering, Perth, Western Australia 6845, Australia;5. Fraunhofer Institute for Industrial Mathematics, Flows and Materials Simulation Department, Kaiserslautern 67663, Germany;1. Group of STCE- Energy Research Center (ERC), Faculty of Science, Mohammed V University, B. P. 1014, Rabat, Morocco;2. LaMCScI, Faculty of Science, Mohammed V University, B. P. 1014, Rabat, Morocco;3. LCMP, Faculty of Sciences, ChouaïbDoukkali University, B. P. 20, El Jadida, Morocco |
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| Abstract: | Protein fouling remains a major problem in the use of microfiltration for many bioprocessing applications. Experiments were performed to evaluate the effect of membrane morphology and pore structure on protein fouling using different track-etched, isotropic, and asymmetric microfiltration membranes. Fouling of membranes with straight-through pores occurred by pore blockage caused by deposition of large protein aggregates on the membrane surface. However, the rate of blockage was a function of the membrane porosity due to the possibility of multiple pore blockage by a single protein aggregate on high porosity membranes. Membranes with interconnected pores fouled more slowly since the fluid could flow around the blocked pores through the interconnected pore structure. This behavior was quantified using model membrane systems with well-defined pore morphology constructed from track-etch and isotropic membranes in a layered series combination. These results provide important insights into the effects of membrane pore structure and morphology on protein fouling. |
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