Synthesis of 1‐H‐1,5‐benzodiazepines derivatives using SiO2/ZnCl2 |
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| Authors: | Raquel G. Jacob,Cá tia S. Radatz,Mariele B. Rodrigues,Diego Alves,Gelson Perin,Eder J. Lenardã o,Lucielli Savegnago |
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| Abstract: | A general and easy method for the synthesis of several 1‐H‐1,5‐benzodiazepines using SiO2/ZnCl2 under solvent‐free conditions is described. This efficient and improved method furnishes selectively and in good yields the corresponding 1‐H‐1,5‐benzodiazepines derivatives starting from o‐phenylenediamine and cyclic or acyclic ketones. The catalytic system was reused up four times, and the use of focused microwaves accelerates the reaction. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:180–185, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20674 |
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