| Abstract: | A novel Lewis acid and Lewis base bifunctional Ti(IV) complex was formed in situ upon the treatment of ligand (R)‐3,3′‐bis(diphenylphosphinoyl)‐BINOL with Ti(PrO‐i)4, which is proven to be an efficient catalyst in the asymmetric trimethylsilylcyanation of aldehydes. The corresponding cyanohydrins were obtained in high to excellent chemical yield (83–93%) albeit with moderate enantioselectivities (up to 51% enantiomeric excess). © 2010 Wiley Periodicals, Inc. Heteroatom Chem 22:31–35, 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20652 |
