Acid-promoted DNA-cleaving activities and total synthesis of varacin C |
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| Authors: | Lee Alex H F Chen Jian Liu Dongsheng Leung Thomas Y C Chan Albert S C Li Tianhu |
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| Affiliation: | Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. |
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| Abstract: | The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions. |
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