Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCl mediated cycloaddition of azlactones |
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| Authors: | Sharma Vasudha Tepe Jetze J |
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| Institution: | Department of Chemistry, Michigan State University, East Lansing, 48823, USA. |
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| Abstract: | reaction: see text] We report herein a trimethylsilyl chloride mediated substrate controlled 1,3-dipolar cycloaddition for the diastereoselective synthesis of either syn- or anti-imidazolines. This method provides scaffolds with four points of diversity and control over two stereocenters. |
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