Polarographic study of a triazolobenzodiazepine: Estazolam |
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| Authors: | R M Jiménez R M Alonso E Oleaga F Vicente and L Hernandez |
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| Institution: | (1) Departamento de Quimica, Facultad de Ciencias, Universidad del Pais Vasco, E-48080 Bilbao, Spain;(2) Departamento de Quimica Analítica, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28034 Madrid, Spain |
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| Abstract: | Summary The polarographic behaviour of 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)-(1,4)-benzodiazepine (estazolam) was studied in the pH range 3–10. The reduction process is irreversible and the current is diffusion-controlled. The linear relationship between current and estazolam concentration permits its polarographic determination in the range 3.4·10–7–1.0·10–4 M. The detection limit was 1.7·10–7 M. The reproducibility of the method in terms of its relative standard deviation was 1.00% and 1.14% using ten determinations at the 2.4·10–5 M and 3.4·10–6 M levels respectively.
Polarographische Untersuchung des Triazolbenzodiazepins Estazolam |
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