Preparation and properties of plasma-initiated graft copolymerized membranes for blood plasma separation |
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| Institution: | 1. School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, South Korea;2. School of Materials Science and Technology, Indian Institute of Technology (BHU), Varanasi 221005, Uttar Pradesh, India;3. School of Chemical Sciences and Advanced Materials Research Centre, Indian Institute of Technology Mandi, H.P. 175075, India;4. Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland;5. Biorefining and Advanced Materials Research Center, SRUC, Barony Campus, Parkgate, Dumfries DG1 3NE, United Kingdom;6. School of Engineering, University of Petroleum & Energy Studies (UPES), Dehradun 248007, Uttarakhand, India;7. Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan;8. Smart Materials, Mads Clausen Institute, University of Southern Denmark, Alsion 2, Sønderborg 6400, Denmark;9. Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK;10. Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA;11. Univ. Lille, CNRS, Univ. Polytechnique Hauts-de-France, UMR 8520 – IEMN, F-59000 Lille, France;12. Max Planck Queensland Centre (MPQC) for the Materials Science of Extracellular Matrices, Queensland University of Technology, Brisbane, QLD 4000, Australia;13. Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia;14. ARC Training Centre for Cell and Tissue Engineering Technologies, Queensland University of Technology, Brisbane, QLD 4000, Australia;15. Australian Research Council (ARC) Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing (M3D Innovation), Queensland University of Technology, Brisbane, QLD 4000, Australia |
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| Abstract: | A hydrophilic composite membrane for blood plasma separation has been prepared by surface graft copolymerization initiated by low-temperature plasma (LTP). After short LTP pre-irradiation onto a microporous polypropylene (PP) membrane, N-N-dimethylacrylamide (DMAA) vapor was introduced for grafting. The PP membrane had a 0.45 μm effective pore size and a 130 μm thickness. The rate of DMAA grafting onto PP was very high, even in vapor-solid phase reaction under reduced pressure; DMAA 1 mm Hg (133Pa). The percentage of grafted poly-DMAA (PDMAA) reached 15% within 5 min post graft polymerization, and the membrane surface, including the interior surface of pores, became completely hydrophilic. There was no apparent change observed in the membrane morphology in the dry state after the PDMAA-grafted layer was formed. However, water flux significantly decreased, probably due to swelling of the PDMAA-grafted layer. With a grafting yield below 17%, the PDMAA-grafted PP (PP-g-PDMAA) membrane showed a good separation capability of plasma from whole blood. The PP-g-PDMAA membrane exhibited low complement activating potential, high sieving coefficient for plasma proteins and high blood compatibility. Decreases in adsorption of blood cells, plasma proteins, and other biomolecules may be the reason for the membrane performance. |
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