The application of phase rotation for localized in Vivo proton spectroscopy with short echo times |
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| Affiliation: | 1. Institute of Diagnostic and Interventional Radiology, Technical University of Munich, School of Medicine;2. Philips Healthcare, Hamburg, Germany;3. Philips Healthcare, Best, The Netherlands;4. Department of Radiology, South Egypt Cancer Institute, Assiut University, Egypt;5. Department of Computing, Faculty of Engineering, Imperial College of Science, Technology and Medicine, United Kingdom;1. GE Healthcare, University of California, San Diego, United States;2. Radiology Department, University of California, San Diego, United States |
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| Abstract: | Single voxel localization techniques like STEAM or PRESS lead to the generation of unwanted signals, which must be destroyed by spoiling gradients. The duration of these gradients and the eddy currents they produce lead to comparatively long echo times on standard whole-body systems. This paper reports a way to observe the proper spectrum in the presence of large spurious signals. The method uses a phase-cycling scheme which separates all different signal contributions by two-dimensional Fourier transformation. Localized proton spectra from the human brain with echo times of 20 ms using the PRESS localization technique could be acquired on a 2 T whole-body system. Metabolites with short T2 relaxation times like glutamate or inositol are observed. |
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