Synthesis of spiro diphosphines and their application in asymmetric hydrogenation of ketones |
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| Authors: | Xie Jian-Hua Wang Li-Xin Fu Yu Zhu Shuo-Fei Fan Bao-Min Duan Hai-Feng Zhou Qi-Lin |
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| Affiliation: | State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China. |
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| Abstract: | Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones. |
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