| 牛磺熊去氧胆酸的合成研究 |
| |
| 引用本文： | 卓超,冯炜,吴达俊,熊志刚.牛磺熊去氧胆酸的合成研究[J].合成化学,2002,10(5):444-446. |
| |
| 作者姓名： | 卓超 冯炜 吴达俊 熊志刚 |
| |
| 作者单位： | 华东理工大学化学与制药学院制药工程系,上海,200237 |
| |
| 摘 要： | 以熊去氧胆酸为原料，先与氯甲酸乙酯形成混酐，再与牛磺酸反应合成牛磺熊去氧胆酸。通优化反应条件、简化后处理等工艺改进，提高了收率，得到了较高纯度的结晶产品。
|
| 关 键 词： | 牛磺熊去氧胆酸 熊去氧胆酸 氯甲酸乙酯 牛磺酸 合成 药物 |
| 文章编号： | 1005-1511(2002)05-444-03 |
| 修稿时间： | 2002年5月14日 |
The Synthesis of Tauroursodeoxycholic Acid |
| |
| ZHUO Chao,FENG Wei,WU Da-jun,XIONG Zhi-gang.The Synthesis of Tauroursodeoxycholic Acid[J].Chinese Journal of Synthetic Chemistry,2002,10(5):444-446. |
| |
| Authors: | ZHUO Chao FENG Wei WU Da-jun XIONG Zhi-gang |
| |
| Abstract: | Tauroursodeoxycholic acid has been synthesized by the reaction of the mixed anhydride of ursodeoxycholic acid and taurine, which is in the form of an aqueous solution of NaOH. The yield of product was increased greatly through the improved reaction conditions. The purification method was also simplified. |
| |
| Keywords: | tauroursodeoxycholic acid ursodeoxycholic acid ethyl chloroformate taurine synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
