Synthesis and crystal structure of 3-chloro-<Emphasis Type="Italic">N</Emphasis>-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-2,2-dimethylpropanamide |
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| Authors: | Email author" target="_blank">Huang?Ming-ZhiEmail author Ma?Yang-Guang Huang?Ke-Long Ren?Ye-Guo Yin?Du-Lin Song?Hai-Bin |
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| Institution: | (1) College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, People’s Republic of China;(2) Hunan Research Institute of Chemical Industry, Changsha, 410007, People’s Republic of China;(3) College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, People’s Republic of China;(4) Research Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People’s Republic of China |
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| Abstract: | The title compound 3-chloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-2,2-dimethylpropanamide was synthesized by the reaction of 2-(5-amino-4-chloro-2-fluorophenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione with 3-chloro-2,2-dimethylpropanoyl chloride. Its structure was determined by X-ray single crystal diffraction. The crystal belongs to triclinic, space group P-1 with the following crystallographic parameters: a = 9.595(3) Å, b = 12.093(4) Å, c = 18.433(6) Å, α = 83.961(5)∘, β = 84.819(5)∘, γ = 67.920(5)∘, μ = 0.361 mm−1, V = 1967.9(10) Å3, Z = 4, Dx = 1.395 mg/m3, F(000) = 856, T = 293(2) K, 1.11∘ ≤ θ ≤ 25.01∘. The X-ray results demonstrated that the reaction of 2-(5-amino-4-chloro-2-fluorophenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione with 3-chloro-2,2-dimethylpropanoyl chloride in tetrahydrofuran at room temperature yielded 3-chloro-N-(2-chloro-5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-4-fluorophenyl)-,2-dimethylpropanamide. |
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| Keywords: | Synthesis crystal structure tetrahydroisoindole-1 3-dione herbicidal protox inhibitors |
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