Viscum album aqueous extract induces NOS-2 and NOS-3 overexpression in Guinea pig hearts |
| |
Authors: | Tenorio-Lopez Fermin Alejandro Valle Mondragon Leonardo Del Olvera Gabriela Zarco Torres Narvaez Juan Carlos Pastelin Gustavo |
| |
Affiliation: | Departamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Sección XVI, 14080 México D.F., México. fatl@att.net.mx |
| |
Abstract: | Viscum album L. aqueous extract, on the Langendorff isolated and perfused heart model, decreases coronary vascular resistance, when compared to control group (36.00 +/- 2.00 vs. 15.80 +/- 1.96 dyn s cm-5). Our data support the fact that this mechanism involves NOS-2 and NOS-3 overexpression (4.65 and 7.89 times over control, respectively), which is correlated with increases in NO (6.24 +/- 2.49 vs. 147.95 +/- 2.79 pmol) and cGMP production (43.94 +/- 2.00 vs. 74.81 +/- 1.96 pmol mg-1 of tissue), compared to control values. Such an effect is antagonized by gadolinium(III) chloride, L-NAME and ODQ. Therefore, coronary vasodilator effect elicited by V. album L. aqueous extract is mediated by the NO/sGC pathway. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|