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Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state |
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| Authors: | Christine B. BaltusNeil J. Press Milan D. AntonijevicGraham J. Tizzard Simon J. ColesJohn Spencer |
| Affiliation: | a School of Science at Medway, University of Greenwich, Chatham, ME4 4TB, UK b Novartis Pharmaceuticals UK, Horsham, Sussex RH12 5AB, UK c National Crystallography Service, School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK |
| Abstract: | A biphenyl library incorporating amide and sulfonamide groups has been synthesised via microwave-mediated Suzuki-Miyaura couplings. Many derivatives were crystallised from dichloromethane/methanol and analysed by single crystal X-ray diffraction. An interesting structure was obtained for N-(4′-methylbiphenyl-4-yl)acetamide with Z′=6 and hydrogen-bonding networks of the type N-H…O in the unit cell. |
| Keywords: | Cross coupling Microwaves Biphenylamides Hydrogen bonds Z&prime X-ray crystallography |
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