Production of lantipeptides in Escherichia coli |
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| Authors: | Shi Yanxiang Yang Xiao Garg Neha van der Donk Wilfred A |
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| Affiliation: | Howard Hughes Medical Institute, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. |
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| Abstract: | Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids. |
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